How would you solve these drug interactions?

Phase 2 of the Drug Interactions Program will test your skills! In these Cases, there are 4 ‘paths’ provided as options – you are expected to choose the path you think best manages the interaction based on your clinical reasoning. You can compare your path against the recommendations of the authors, and also against the paths others who are completing the adventures have taken. We’re looking forward to seeing what path you choose! (You need to sign in as a member to view the cases.)
Case 1: Solving PK's Pharmacokinetic Problems
PK is a 54-year-old male with transitional cell carcinoma of the urinary tract. He is diagnosed with a high-risk tumour, staged at pT3b, node positive, which has been completely resected. His oncology healthcare team decides to initiate a protocol1 containing methotrexate, vinblastine, doxorubicin and cisplatin as adjuvant therapy along with an appropriate anti-emetic regimen …
By Nicole MacDonald, BScPharm, ACPR and Jennifer Jupp, BScPharm, BCOP
Case 2: Resolving DI's Drug Interactions
DI is a 67-year-old male with chronic lymphocytic leukemia. Unfortunately, his disease progressed after first-line treatment with bendamustine and rituximab therapy and his Hematology healthcare team decides to initiate ibrutinib as second-line therapy …
By Tiffany Nguyen, BScPharm, ACPR, BCOP and Beverly Dawson, BScPharm, BCPS, PharmD
Case 3: Addressing Mrs. DP’s DTPs
During your morning review of new admissions on your oncology service, you meet Mrs. DP, a lovely 77-year-old woman who was admitted overnight from her assisted living residence. Mrs. DP has about a 5-day history of worsening nausea and fatigue, increased cough and work of breathing with shortness of breath on exertion that is affecting her activity of daily living. Further investigation reveals she is having difficulty swallowing and has had decreased oral intake over the past week (although she can still manage to swallow medications) ... She is admitted to your service for hydration and further investigation …
By Jason R. Wentzell, BScPharm, ACPR, BCOP and Danica Wasney, BScPharm, ACPR, BCOP
The NEW Drug Interactions Program is a key educational initiative that has been developed by the Drug Interactions Task Force with the objective of providing practical strategies to managing common drug interactions encountered in oncology practice.
Don't miss the opportunity to take part in this valuable educational initiative! If you have any questions about the Drug Interactions Program, please contact me at
Glenn Myers
Chair, Education Committee - Pharmacist Advanced